Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H-Ile- NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I | - |
Human T-cell leukemia virus type I | |
H-Pro-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I | - |
Human T-cell leukemia virus type I | |
H-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-Ile-NHCH2C6H5I | - |
Human T-cell leukemia virus type I | |
H-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I | - |
Human T-cell leukemia virus type I | |
H-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-Ile-NHCH2C6H5I | - |
Human T-cell leukemia virus type I | |
H-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I | - |
Human T-cell leukemia virus type I | |
additional information | results show that a tetrapeptide sequence is necessary to achieve potent inhibition | Human T-cell leukemia virus type I |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human T-cell leukemia virus type I | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
KGPPVICPIQA + H2O | the preferred amino acids at the P1 position, except for Leu, are hydrophobic Phe and sulfur-containing amino acids (Met and Cys). Substrates which contain a charged side chain at the P1 position are not cleaved | Human T-cell leukemia virus type I | KGPPVIC + PIQA | - |
? | |
KGPPVIFPIQA + H2O | the preferred amino acids at the P1 position, except for Leu, are hydrophobic Phe and sulfur-containing amino acids (Met and Cys). Substrates which contain a charged side chain at the P1 position are not cleaved | Human T-cell leukemia virus type I | KGPPVIF + PIQA | - |
? | |
KGPPVILPIQA + H2O | Pro residue at the P1' position is the preferred amino acid for hydrolysis, and no replacement at the P1' position seems to be tolerated | Human T-cell leukemia virus type I | KGPPVIL + PIQA | - |
? | |
KGPPVILPIQAP + H2O | 12-residue standard peptide, 100% cleavage | Human T-cell leukemia virus type I | ? | - |
? | |
KGPPVIMPIQA + H2O | the preferred amino acids at the P1 position, except for Leu, are hydrophobic Phe and sulfur-containing amino acids (Met and Cys). Substrates which contain a charged side chain at the P1 position are not cleaved | Human T-cell leukemia virus type I | KGPPVIM + PIQA | - |
? | |
additional information | no cleavage using substrates: VILPIQAP, VILPIQA, VILPIQ, PPVILPI, PVILPI | Human T-cell leukemia virus type I | ? | - |
? | |
additional information | preference for Pro at the P1' position and for Ile at the P2 position. Hydrophobic Phe and Gln residues are acceptable in the P3 position and a Gln residue at the P4 position | Human T-cell leukemia virus type I | ? | - |
? | |
PPVILPIQ + H2O | - |
Human T-cell leukemia virus type I | ? | - |
? | |
PPVILPIQA + H2O | a 9-residue peptide is cleaved approximately at 85% of the 12-residue standard peptide | Human T-cell leukemia virus type I | ? | - |
? | |
PPVILPIQAP + H2O | - |
Human T-cell leukemia virus type I | ? | - |
? | |
PVILPIQ + H2O | minimal sequence required for substrate recognition is a 7-residue peptide | Human T-cell leukemia virus type I | ? | - |
? | |
PVILPIQA + H2O | - |
Human T-cell leukemia virus type I | ? | - |
? | |
PVILPIQAP + H2O | - |
Human T-cell leukemia virus type I | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C2A HTLV-1 PR | chemically synthesized mutant of HTLV-1 protease | Human T-cell leukemia virus type I |
HTLV-1 protease | - |
Human T-cell leukemia virus type I |
HTLV-I protease | - |
Human T-cell leukemia virus type I |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Human T-cell leukemia virus type I |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00013 | - |
- |
Human T-cell leukemia virus type I | H-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-Ile-NHCH2C6H5I | |
0.0024 | - |
- |
Human T-cell leukemia virus type I | H-Pro-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I | |
0.0058 | - |
- |
Human T-cell leukemia virus type I | H-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I | |
0.0183 | - |
- |
Human T-cell leukemia virus type I | H-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-Ile-NHCH2C6H5I | |
0.0196 | - |
- |
Human T-cell leukemia virus type I | H-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I |