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Literature summary for 3.4.23.B8 extracted from

  • Ha, J.J.; Gaul, D.A.; Mariani, V.L.; Ding, Y.S.; Ikeda, R.A.; Shuker, S.B.
    HTLV-I protease cleavage of P19/24 substrates is not dependent on NaCl concentration (2002), Bioorg. Chem., 30, 138-144.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Human T-cell leukemia virus type I

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.055
-
4-((4-dimethylaminophenylazo)benzoyl)-(gamma-aminobutyric acid)-PQVL-(4-nitro)Phe-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) pH 5.2, 37°C Human T-cell leukemia virus type I
0.058
-
(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-F(NO2)-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) pH 5.2, 37°C Human T-cell leukemia virus type I
0.06
-
(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-PVMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) pH 5.2, 37°C Human T-cell leukemia virus type I

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-F(NO2)-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) + H2O
-
Human T-cell leukemia virus type I (((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL + F(NO2)-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid)
-
?
(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-PVMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) + H2O
-
Human T-cell leukemia virus type I (((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL + PVMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid)
-
?
4-((4-dimethylaminophenylazo)benzoyl)-(gamma-aminobutyric acid)-PQVL-(4-nitro)Phe-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) + H2O
-
Human T-cell leukemia virus type I ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35 40
-
Human T-cell leukemia virus type I

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.2
-
(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-F(NO2)-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) pH 5.2, 37°C Human T-cell leukemia virus type I
0.2
-
(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-PVMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) pH 5.2, 37°C Human T-cell leukemia virus type I
0.2
-
4-((4-dimethylaminophenylazo)benzoyl)-(gamma-aminobutyric acid)-PQVL-(4-nitro)Phe-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid) pH 5.2, 37°C Human T-cell leukemia virus type I

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.2 5.3
-
Human T-cell leukemia virus type I

pH Range

pH Minimum pH Maximum Comment Organism
5 5.4 pH 5.0: about 40% of maximal activity, pH 5.4: about 55% of maximal activity Human T-cell leukemia virus type I