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Literature summary for 3.4.23.B8 extracted from

  • Tözser, J.; Zahuczky, G.; Bagossi, P.; Louis, J.M.; Copeland, T.D.; Oroszlan, S.; Harrison, R.W.; Weber, I.T.
    Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases (2000), Eur. J. Biochem., 267, 6287-6295.
    View publication on PubMed
Search for more literature for 3.4.23.B8

Application

Application Comment Organism
medicine HTLV-1 is associated with a number of human diseases. HTLV-1 is a potential target for chemotherapy Human T-cell leukemia virus type I

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 KTKLLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.04
-
 KTKILVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.049
-
 KTKVFVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.053
-
 KTSVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.062
-
 KTGVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.063
-
 KTKVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.069
-
 KGKVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.086
-
 KAKVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.087
-
 TKVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.12
-
 KTKVLIVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.12
-
 KTKVGVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.13
-
 KTFVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.15
-
 KTKVMVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.18
-
 KTKVLFVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.18
-
 KTDVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.19
-
 KTKVAVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.19
-
 KTKVYVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.23
-
 KSKVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I
0.26
-
 VSQLYPIVQ pH 5.6, 37°C Human T-cell leukemia virus type I
0.26
-
 VSQIYPIVQ pH 5.6, 37°C Human T-cell leukemia virus type I
0.42
-
 VSQVYPIVQ pH 5.6, 37°C Human T-cell leukemia virus type I
0.48
-
 KDKVLVVQPK 5.6, 37°C Human T-cell leukemia virus type I

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human T-cell leukemia virus type I the cleavage site between the capsid and the nucleocapsid protein of HTLV-1 is evolutionary optimized for rapid hydrolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KAKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KAKVL + VVQPK
-
 ?
KDKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KDKVL + VVQPK
-
 ?
KGKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KGKVL + VVQPK
-
 ?
KGVKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KGKVL + VVQPK
-
 ?
KLKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KLKVL + VVQPK
-
 ?
KPVKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KPKVL + VVQPK
-
 ?
KSKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KSKVL + VVQPK
-
 ?
KTAVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTAVL + VVQPK
-
 ?
KTDVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTDVL + VVQPK
-
 ?
KTFVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTFVL + VVQPK
-
 ?
KTGVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTGVL + VVQPK
-
 ?
KTKFLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKFL + VVQPK
-
 ?
KTKILVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKIL + VVQPK
-
 ?
KTKLLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKLL + VVQPK
-
 ?
KTKVAVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVA + VVQPK
-
 ?
KTKVFVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVF + VVQPK
-
 ?
KTKVGFVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVG + FVQPK
-
 ?
KTKVGIVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVG + IVQPK
-
 ?
KTKVGVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVG + VVQPK
-
 ?
KTKVLFVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVL + FVQPK
-
 ?
KTKVLIVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVL + IVQPK
-
 ?
KTKVLLVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVL + LVQPK
-
 ?
KTKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVL + VVQPK
-
 ?
KTKVMGVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVM + VVQPK
-
 ?
KTKVMVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVM + VVQPK
-
 ?
KTKVYVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVY + VVQPK
-
 ?
KTLVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTLVL + VVQPK
-
 ?
KTSVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTSVL + VVQPK
-
 ?
KTVVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTVVL + VVQPK
-
 ?
KVKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KVKVL + VVQPK
-
 ?
additional information the original HIV-1 matrix/capsid cleavage site substrate and most of its substituted peptides are not hydrolyzed by the HTLV-1 enzyme Human T-cell leukemia virus type I ?
-
 ?
additional information the cleavage site between the capsid and the nucleocapsid protein of HTLV-1 is evolutionary optimized for rapid hydrolysis Human T-cell leukemia virus type I ?
-
 ?
TKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I TKVL + VVQPK
-
 ?
VLQLYPIVQ + H2O
-
 Human T-cell leukemia virus type I VLQLY + PIVQ
-
 ?
VMQIYPIVQ + H2O
-
 Human T-cell leukemia virus type I VMQIY + PIVQ
-
 ?
VSQIYPIVQ + H2O
-
 Human T-cell leukemia virus type I VSQIY + PIVQ
-
 ?
VSQLYPIVQ + H2O
-
 Human T-cell leukemia virus type I VSQLY + PIVQ
-
 ?
VSQVYPIVQ + H2O
-
 Human T-cell leukemia virus type I VSQVY + PIVQ
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
 VSQVYPIVQ pH 5.6, 37°C Human T-cell leukemia virus type I
0.05
-
 VSQLYPIVQ pH 5.6, 37°C Human T-cell leukemia virus type I
0.05
-
 VSQIYPIVQ pH 5.6, 37°C Human T-cell leukemia virus type I
0.27
-
 KTKVGVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
0.36
-
 KTKVLFVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
0.44
-
 KTFVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
0.48
-
 KTVVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
0.52
-
 KTLVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
1.1
-
 KDKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
1.2
-
 KTGVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
1.5
-
 KTKVLIVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
1.5
-
 KTKFLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.08
-
 KTSVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.3
-
 KPKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.3
-
 KTDVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.4
-
 KTAVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.5
-
 KTKILVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.5
-
 KLKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.7
-
 TKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
2.7
-
 KVKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
3.1
-
 KAKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
3.3
-
 KTKLLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
3.7
-
 KTKVLLVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
4.1
-
 KTKVMVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
5.7
-
 KTKVAVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
6.8
-
 KGKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
9.2
-
 KSKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
10
-
 KTKVLVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
11.7
-
 KTKVYVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I
16.4
-
 KTKVFVVQPK pH 5.6, 37°C Human T-cell leukemia virus type I