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Literature summary for 3.4.23.B6 extracted from
- Mason-Pfizer monkey virus retropepsin (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ), 1, 172-174.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | activates at 2 M | Mason-Pfizer monkey virus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli in inclusion bodies | Mason-Pfizer monkey virus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure determination of p12 mutant D26N/C7A/C106A | Mason-Pfizer monkey virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D26N/C7A/C106A | mutant of isozyme p12 showing altered structure and low target functions | Mason-Pfizer monkey virus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 12000 | - |
2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
| 13000 | - |
2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
| 17000 | - |
2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
| 26000 | - |
x * 26000, recombinant enzyme, SDS-PAGE | Mason-Pfizer monkey virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gag polyprotein + H2O | Mason-Pfizer monkey virus | processing of the precursor protein into mature proteins and the functional protease | ? | - |
? | |
| Gag-Pol polyprotein + H2O | Mason-Pfizer monkey virus | processing of the precursor protein into mature proteins and the functional protease | ? | - |
? | |
| additional information | Mason-Pfizer monkey virus | the enzyme is involved in core disintegration cleaving the capsid protein within the major homology region, the enzyme also converts the cell-associated transmembrane protein to a virus-associated gp20 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mason-Pfizer monkey virus | - |
P-MPV, a simian type D virus 1 retrovirus, three proteinase isozymes p17, p13, and p12 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATPQVYF(NO2)VRKA + H2O | - |
Mason-Pfizer monkey virus | ATPQVY + F(NO2)VRKA | - |
? | |
| Gag polyprotein + H2O | - |
Mason-Pfizer monkey virus | ? | - |
? | |
| Gag polyprotein + H2O | processing of the precursor protein into mature proteins and the functional protease | Mason-Pfizer monkey virus | ? | - |
? | |
| Gag-Pol polyprotein + H2O | - |
Mason-Pfizer monkey virus | ? | - |
? | |
| Gag-Pol polyprotein + H2O | processing of the precursor protein into mature proteins and the functional protease | Mason-Pfizer monkey virus | ? | - |
? | |
| additional information | the enzyme is involved in core disintegration cleaving the capsid protein within the major homology region, the enzyme also converts the cell-associated transmembrane protein to a virus-associated gp20 | Mason-Pfizer monkey virus | ? | - |
? | |
| additional information | cleavage site specificity, overview | Mason-Pfizer monkey virus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 26000, recombinant enzyme, SDS-PAGE | Mason-Pfizer monkey virus |
| dimer | 2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
| More | isozyme p12 structure analysis | Mason-Pfizer monkey virus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Mason-Pfizer leukemia virus retropepsin | - |
Mason-Pfizer monkey virus |
| Mason-Pfizer monkey virus retropepsin | - |
Mason-Pfizer monkey virus |
| More | the enzyme belongs to the A2 peptidase family | Mason-Pfizer monkey virus |
| P-MPV poteinase | - |
Mason-Pfizer monkey virus |
| P-MPV PR | - |
Mason-Pfizer monkey virus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
- |
Mason-Pfizer monkey virus |
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