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Literature summary for 3.4.23.B3 extracted from

  • Gustchina, A.; Kervinen, J.; Powell, D.J.; Zdanov, A.; Kay, J.; Wlodawer, A.
    Structure of equine infectious anemia virus proteinase complexed with an inhibitor (1996), Protein Sci., 5, 1453-1465.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of the mutant enzyme I54G in Escherichia coli. The wild-type enzyme does not accumulate in Escherichia coli at a level sufficient for purifying enough material to homogeneity for crystallization equine infectious anemia virus

Crystallization (Commentary)

Crystallization (Comment) Organism
complex of the 154G mutant enzyme with the inhibitor HBY-793, hanging-drop vapor diffusion method equine infectious anemia virus

Inhibitors

Inhibitors Comment Organism Structure
HBY-793
-
equine infectious anemia virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information equine infectious anemia virus the enzyme processes viral polyproteins into functional molecules during replication and it also cleaves viral nucleocapsid protein during infection ?
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?

Organism

Organism UniProt Comment Textmining
equine infectious anemia virus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme processes viral polyproteins into functional molecules during replication and it also cleaves viral nucleocapsid protein during infection equine infectious anemia virus ?
-
?

Subunits

Subunits Comment Organism
dimer the molecule is a dimer in which the monomers are related by a crystallographic twofold axis equine infectious anemia virus