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Literature summary for 3.4.23.B24 extracted from

  • Baldwin, M.; Russo, C.; Li, X.; Chishti, A.H.
    Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis (2014), Biochem. Biophys. Res. Commun., 450, 1427-1432.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.B24

Application

Application Comment Organism
medicine malaria heat shock protein 101 is a substrate, and partial inhibition of Plasmodium falciparum signal peptide peptidase correlates with the emergence of gametocytes Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
1,3-di-(N-carboxybenzoyl-L-leucyl-L-leucyl) amino acetone
-
 Plasmodium falciparum
[(2R,4R,5S)-2-benzyl-5-(t-butyloxycarbonylamino)-4-hydroxy-6-phenylhexanoyl]-L-leucyl-L-phenylalanine amide
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Plasmodium falciparum 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 1 * 35000, SDS-PAGE, and dimer Plasmodium falciparum
35000
-
 2 * 35000, SDS-PAGE, and monomer Plasmodium falciparum
65000
-
 immunoprecipitation and PAGE Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum C0KWU7
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heat shock protein 101 + H2O
-
 Plasmodium falciparum ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 35000, SDS-PAGE, and monomer Plasmodium falciparum
monomer 1 * 35000, SDS-PAGE, and dimer Plasmodium falciparum