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Literature summary for 3.4.23.B2 extracted from

  • Rue, S.M.; Roos, J.W.; Tarwater, P.M.; Clements, J.E.; Barber, S.A.
    Phosphorylation and proteolytic cleavage of Gag proteins in budded simian immunodeficiency virus (2005), J. Virol., 79, 2484-2492.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.B2

Protein Variants

Protein Variants Comment Organism
additional information generation of an protease-inactive mutant of SIVmac239, the phosphorylation pattern of the mutant Pr55Gag protein is unaltered compared to the wild-type, overview Simian immunodeficiency virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Pr55Gag polyprotein + H2O Simian immunodeficiency virus lentiviral Gag polyprotein, proteolytic processing for activation, cleavage in the late stages of life cycle, required for maturation of the virion meaning a structural rearrangement required for infectivity in budding virions, cleavage in the phosphorylated capsid domains, the enzyme is not influenced by the preceeding phosphorylation, but cleaved sites are no longer phosphorylated, while incompletely cleaved capsid domains are phosphorylated to a greater extent, overview ?
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Organism

Organism UniProt Comment Textmining
Simian immunodeficiency virus
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 SIV, a lenti-retrovirus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Pr55Gag polyprotein + H2O lentiviral Gag polyprotein, proteolytic processing for activation, cleavage in the late stages of life cycle, required for maturation of the virion meaning a structural rearrangement required for infectivity in budding virions, cleavage in the phosphorylated capsid domains, the enzyme is not influenced by the preceeding phosphorylation, but cleaved sites are no longer phosphorylated, while incompletely cleaved capsid domains are phosphorylated to a greater extent, overview Simian immunodeficiency virus ?
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 ?
Pr55Gag polyprotein + H2O lentiviral Gag polyprotein, cleavage in the phosphorylated capsid domains, the enzyme is not influenced by the preceeding phosphorylation, but cleaved sites are no longer phosphorylated, while incompletely cleaved capsid domains are phosphorylated to a greater extent, overview Simian immunodeficiency virus ?
-
 ?

Synonyms

Synonyms Comment Organism
simian immunodeficiency virus retropepsin
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 Simian immunodeficiency virus
SIV retropepsin
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 Simian immunodeficiency virus