Literature summary for 3.4.23.B2 extracted from

Caldera, P.S.; Yu, Z.; Knegtel, R.M.; McPhee, F.; Burlingame, A.L.; Craik, C.S.; Kuntz, I.D.; Ortiz de Montellano, P.R.
Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor (1997), Bioorg. Med. Chem., 5, 2019-2027.

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Inhibitors

Inhibitors	Comment	Organism	Structure
9H-fluoren-9-ylmethyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate	specific irreversible inhibition, t1/2 for inactivation is 240 min with a 0.1 mM inhibitor concentration	Simian immunodeficiency virus
additional information	development of a more efficient irreversible inhibitor can be achieved by optimizing the interactions of the inhibitor with the protein while preserving the favorable reactivity and orientation of the epoxide moiety	Simian immunodeficiency virus
U-85548	i.e. Val-Ser-Gln-Asn-Leu-PSI[CH(OH)CH2]-Val-Ile-Val	Simian immunodeficiency virus

Organism

Organism	UniProt	Comment	Textmining
Simian immunodeficiency virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aminobenzoyl-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2 + H2O	-	Simian immunodeficiency virus	?	-	?

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Release 2023.1 (January 2023)