Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cholic acid | inhibitory to both the separate protease domain and to protease-reverse transcriptase. Cholic acid binds in the proposed protease domain dimerization interface and appears to impair formation of the correct dimer | Simian foamy virus | |
lithocholic acid | - |
Simian foamy virus | |
additional information | HIV-1 inhibitors darunavir, tipranavir, and indinavir, have no effect on foamy virus protease in vitro | Simian foamy virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Simian foamy virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GB1-GFP + H2O | peptide substrate, harboring the simian foamy virus mac reverse transcriptase-viral integrase cleavage site of the Pol polyprotein, ATQGSYVVHCNTTP, between immunoglobulin binding domain B1 of streptococcal protein G, GB1, and green fluorescent protein, GFP | Simian foamy virus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | transient homodimers of the seaprate protease domain are formed under native conditions but are only present as a minor transient species, which is not detectable by traditional methods | Simian foamy virus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.6 | - |
separate protease domain, pH 6.4, 20°C, presence of 3 M NaCl | Simian foamy virus | cholic acid | |
0.75 | - |
protease-reverse transcriptase, pH 6.4, 20°C, presence of 3 M NaCl | Simian foamy virus | cholic acid | |
1 | - |
protease-reverse transcriptase, pH 6.4, 20°C, presence of 3 M NaCl | Simian foamy virus | lithocholic acid |