Literature summary for 3.4.23.B10 extracted from

Dong, J.Y.; Dubay, J.W.; Perez, L.G.; Hunter, E.
Mutations within the proteolytic cleavage site of the Rous sarcoma virus glycoprotein define a requirement for dibasic residues for intracellular cleavage (1992), J. Virol., 66, 865-874.

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Organism

Organism	UniProt	Comment	Textmining
Rous sarcoma virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Rous sarcoma virus glycoprotein precursor + H2O	the enzyme has a stringent requirement for the presence of a pair of basic residues (Arg-Arg or Lys-Arg), when the cleavage sequence is deleted or modified to contain unpaired basic residues, intracellular cleavage of the glycoprotein precursor is completely blocked	Rous sarcoma virus	?	-	?

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Release 2023.1 (January 2023)