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Literature summary for 3.4.23.B1 extracted from

  • Cronshaw, R.F.; Schauer-Vukasinovic, V.; Powell, D.J.; Giller, T.; Bur, D.; Kay, J.
    Inhibition of human napsin A (2003), Protein Pept. Lett., 10, 35-42.
    View publication on PubMed
Search for more literature for 3.4.23.B1

Inhibitors

Inhibitors Comment Organism Structure
17 kDa protein of Ascaris lumbricoides weak inhibition Homo sapiens
ABT-538 HIV proteinase inhibitor Homo sapiens
Ac-Phe-His-(4-amino-3-hydroxy-6-methylheptanoic acid)-Leu-Phe-NH2
-
 Homo sapiens
ethoxycarbonyl-Phe-His-(4-amino-3-hydroxy-6-methylheptanoic acid)-Leu-Phe-NH2
-
 Homo sapiens
isobutyryl-HPFA-statine-LF-NH2
-
 Homo sapiens
isobutyryl-HPFH-statine-LF-NH2
-
 Homo sapiens
isobutyryl-HPFY-statine-LF-NH2
-
 Homo sapiens
isovaleryl-HPF-2-naphthylalanine-statine-LF-NH2
-
 Homo sapiens
isovaleryl-HPF-homophenylalanine-statine-LF-NH2
-
 Homo sapiens
isovaleryl-HPFH-(4-amino-3-hydroxy-5-phenylpentanoic acid)-LF-NH2
-
 Homo sapiens
isovaleryl-HPFH-(4-amino-3-hydroxy-6-methylheptanoic acid)-LF-NH2
-
 Homo sapiens
isovaleryl-HPFH-statine-delta-N-acetylornithine-F-NH2
-
 Homo sapiens
isovaleryl-HPFH-statine-IF-NH2
-
 Homo sapiens
isovaleryl-HPFH-statine-IH-NH2
-
 Homo sapiens
isovaleryl-HPFH-statine-LF-NH2
-
 Homo sapiens
isovaleryl-pepstatin strong inhibition Homo sapiens
lactoyl-pepstatin strong inhibition Homo sapiens
t-butoxycarbonyl-HPFH-statine-LF-NH2
-
 Homo sapiens
t-butoxycarbonyl-Phe-His-(4-amino-3-hydroxy-6-methylheptanoic acid)-Leu-Phe-NH2
-
 Homo sapiens
t-butoxycarbonyl-Phe-His-statine-Leu-Phe-NH2
-
 Homo sapiens
TLIRIPLHRVQPGRRILNL biotinylated, derived from residues 1P-19P of the 34 amino acid propart of pronapsin A Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O96009
-
-

Reaction

Reaction Comment Organism Reaction ID
belongs to the aspartic proteinases active site S1/S3 region Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
K(dabsyl)-TSVLMAAPQ-Lucifer yellow + H2O synthetic fluorogenic substrate Homo sapiens K(dabsyl)-TSVL + MAAPQ-Lucifer yellow
-
 ?
polypeptide + H2O
-
 Homo sapiens peptides
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.7
-
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000015
-
 isovaleryl-pepstatin pH 4.7, 37°C Homo sapiens
0.000003
-
 isovaleryl-HPF-homophenylalanine-statine-LF-NH2 pH 4.7, 37°C Homo sapiens
0.00001
-
 Ac-Phe-His-(4-amino-3-hydroxy-6-methylheptanoic acid)-Leu-Phe-NH2 pH 4.7, 37°C Homo sapiens
0.000012
-
 t-butoxycarbonyl-Phe-His-statine-Leu-Phe-NH2 pH 4.7, 37°C Homo sapiens
0.000012
-
 isovaleryl-HPFH-(4-amino-3-hydroxy-5-phenylpentanoic acid)-LF-NH2 pH 4.7, 37°C Homo sapiens
0.000016
-
 lactoyl-pepstatin pH 4.7, 37°C Homo sapiens
0.00002
-
 ethoxycarbonyl-Phe-His-(4-amino-3-hydroxy-6-methylheptanoic acid)-Leu-Phe-NH2 pH 4.7, 37°C Homo sapiens
0.000055
-
 isovaleryl-HPFH-statine-IF-NH2 pH 4.7, 37°C Homo sapiens
0.000065
-
 isovaleryl-HPFH-(4-amino-3-hydroxy-6-methylheptanoic acid)-LF-NH2 pH 4.7, 37°C Homo sapiens
0.00007
-
 isobutyryl-HPFA-statine-LF-NH2 pH 4.7, 37°C Homo sapiens
0.000105
-
 isovaleryl-HPF-2-naphthylalanine-statine-LF-NH2 pH 4.7, 37°C Homo sapiens
0.00011
-
 ABT-538 pH 4.7, 37°C Homo sapiens
0.00014
-
 isovaleryl-HPFH-statine-delta-N-acetylornithine-F-NH2 pH 4.7, 37°C Homo sapiens
0.00016
-
 isobutyryl-HPFH-statine-LF-NH2 pH 4.7, 37°C Homo sapiens
0.000185
-
 t-butoxycarbonyl-Phe-His-(4-amino-3-hydroxy-6-methylheptanoic acid)-Leu-Phe-NH2 pH 4.7, 37°C Homo sapiens
0.0002
-
 isovaleryl-HPFH-statine-LF-NH2 pH 4.7, 37°C Homo sapiens
0.0005
-
 TLIRIPLHRVQPGRRILNL pH 4.7, 37°C Homo sapiens
0.00057
-
 isovaleryl-HPFH-statine-IH-NH2 pH 4.7, 37°C Homo sapiens
0.0006
-
 17 kDa protein of Ascaris lumbricoides pH 4.7, 37°C Homo sapiens
0.001
-
 isobutyryl-HPFY-statine-LF-NH2 pH 4.7, 37°C Homo sapiens
0.003
-
 t-butoxycarbonyl-HPFH-statine-LF-NH2 pH 4.7, 37°C Homo sapiens