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Literature summary for 3.4.23.50 extracted from

  • Padow, M.; Lai, L.; Fisher, R.J.; Zhou, Y.C.; Wu, X.; Kappes, J.C.; Towler, E.M.
    Analysis of human immunodeficiency virus type 1 containing HERV-K protease (2000), AIDS Res. Hum. Retroviruses, 16, 1973-1980.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
targeting of the HERV-K PR to protease-deficient HIV-1 virions by expressing it as a Vpr fusion partner. The Vpr fusion proteins are sucessfully delivered to the HIV-1 virions, where the HERV-K PR not only autoprocesses itself to ist mature form, but also cleaves a number of HIV-1 polyproteins Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the results do not exclude the possibility that the HERV-K PR could complement an HIV-1 PR whoses function is impaired due to drugs or drug-resistant mutations, they clearly demomstrate that the HERV-K PR cannot substitute for the function of the wild-type HIV-1 PR ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HIV-1 matrix-capsid polyprotein + H2O cleavage also in presence of HIV-1 PR inhibitor Homo sapiens ?
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?
additional information the results do not exclude the possibility that the HERV-K PR could complement an HIV-1 PR whoses function is impaired due to drugs or drug-resistant mutations, they clearly demomstrate that the HERV-K PR cannot substitute for the function of the wild-type HIV-1 PR Homo sapiens ?
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?