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Literature summary for 3.4.23.5 extracted from

  • Cocchiaro, P.; Fox, C.; Tregidgo, N.W.; Howarth, R.; Wood, K.M.; Situmorang, G.R.; Pavone, L.M.; Sheerin, N.S.; Moles, A.
    Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury (2016), Sci. Rep., 6, 27112 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
CTSD
-
 Mus musculus
pro-CtsD proenzyme Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is upregulated in damaged tubular cells in nephrotoxic and ischemia reperfusion induced acute kidney injury. Enzyme expression is increased during acute tubular necrosis in transplanted kidneys up

General Information

General Information Comment Organism
malfunction enzyme inhibition leads to an improvement in kidney function, a reduction in apoptosis and a decrease in tubular cell damage in kidneys with nephrotoxic or ischemia reperfusion-induced acute kidney injury Mus musculus
physiological function the enzyme plays a role in apoptosis during acute kidney injury Mus musculus