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Literature summary for 3.4.23.5 extracted from

  • Butler, V.J.; Cortopassi, W.A.; Argouarch, A.R.; Ivry, S.L.; Craik, C.S.; Jacobson, M.P.; Kao, A.W.
    Progranulin stimulates the in vitro maturation of pro-cathepsin D at acidic pH (2019), J. Mol. Biol., 431, 1038-1047 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.5

Activating Compound

Activating Compound Comment Organism Structure
progranulin stimulates the in vitro maturation of the proenzyme at acidic pH Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293FT cells Homo sapiens

General Stability

General Stability Organism
the addition of progranulin to the proenzyme at a 3:1 molar ratio causes a significant destabilizing effect on the melting temperature of the proenzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MOCAc-Lys-Arg-Gly-Leu-Tyr-Phe-Ile-Thr-His-Lys(Dnp) + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 52000, proenzyme, SDS-PAGE Homo sapiens
? x * 30000 + x * 15000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
matCTSD mature enzyme Homo sapiens
proCTSD inactive precursor Homo sapiens