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Literature summary for 3.4.23.5 extracted from

  • Zeleznik, T.Z.; Kadin, A.; Turk, V.; Dolenc, I.
    Aspartic cathepsin D degrades the cytosolic cysteine cathepsin inhibitor stefin B in the cells (2015), Biochem. Biophys. Res. Commun., 465, 213-217 .
    View publication on PubMed
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
lysosome
-
 Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stefin B + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
FRTL-5 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stefin B + H2O
-
 Rattus norvegicus ?
-
 ?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
CatD
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the enzyme expression is not influenced by the lysosomotropic agent Leu-Leu-OMe additional information

General Information

General Information Comment Organism
physiological function the presence of cathepsin D in the cytosol affects the inhibitory potency of stefin B, thus preventing the regulation of cysteine cathepsin activities in various biological processes Rattus norvegicus