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Literature summary for 3.4.23.5 extracted from
- Two faces of cathepsin D: physiological guardian angel and pathological demon (2014), Biol. Med. (Aligarh), 6, 1000206.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| extracellular | - |
Homo sapiens | - |
- |
| lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
| 34000 | - |
1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Hemoglobin + H2O | Homo sapiens | - |
? | - |
? |  |
| additional information | Homo sapiens | Man-6PR, prosaposin, ceramide, low-density lipoprotein receptor-related protein-1, maspin, sortilin, and cystatin C are cathespin D binding partner | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P07339 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme is glycosylated at two N-linked glycosylation sites (Asn residues 134 and 263) | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-7 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
| MDA-MB231 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Albumin + H2O | - |
Homo sapiens | ? | - |
? | |
| Hemoglobin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | Man-6PR, prosaposin, ceramide, low-density lipoprotein receptor-related protein-1, maspin, sortilin, and cystatin C are cathespin D binding partner | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CatD | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | epidermal growth factor rapidly induces enzyme mRNA by 2-4fold. Cathepsin D is overexpressed in breast cancer | up |
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Release 2023.1 (January 2023)
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