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Literature summary for 3.4.23.5 extracted from

  • Bewley, M.A.; Marriott, H.M.; Tulone, C.; Francis, S.E.; Mitchell, T.J.; Read, R.C.; Chain, B.; Kroemer, G.; Whyte, M.K.; Dockrell, D.H.
    A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci (2011), PLoS Pathog., 7, e1001262.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.5

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Expression

Organism Comment Expression
Mus musculus Streptomyces pneumonia (strain D39) triggers activation of cathepsin D in macrophages about 2fold up

General Information

General Information Comment Organism
malfunction pharmacological inhibition or knockout of cathepsin D during pneumococcal infection blocks macrophage apoptosis. Inhibition of cathepsin D has no effect on early bacterial killing but inhibits the late phase of apoptosis-associated killing of pneumococci in vitro. Cathepsin deficient mice demonstrate reduced macrophage apoptosis in vivo, with decreased clearance of pneumococci and enhanced recruitment of neutrophils to control pulmonary infection. Cathepsin D enhances Mcl-1 ubiquitination Mus musculus
physiological function cathepsin D mediates a lysosomal pathway of macrophage apoptosis in pulmonary host defense against pneumococci Mus musculus