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Literature summary for 3.4.23.5 extracted from

  • Fan, X.; Luo, G.; Yang, D.; Ming, M.; Liu, H.; Pu, P.; Le, W.
    Critical role of lysosome and its associated protein cathepsin D in manganese-induced toxicity in cultured midbrain astrocyte (2010), Neurochem. Int., 56, 291-300.
    View publication on PubMed
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A specific cathepsin D inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol in manganese treated astrocyte, cathepsin D is distributed uniformly in the cytosol Mus musculus 5829
-
lysosome the mature form of cathepsin D is located at lysosome Mus musculus 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
14000
-
 1 * 34000 + 1 * 14000, mature form of cathepsin D, SDS-PAGE Mus musculus
34000
-
 mature form of cathepsin D, SDS-PAGE Mus musculus
48000
-
 intermediate form of cathepsin D, SDS-PAGE Mus musculus
52000
-
 immature, inactive precursor of cathepsin D, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
midbrain
-
 Mus musculus
-

Subunits

Subunits Comment Organism
heterodimer 1 * 34000 + 1 * 14000, mature form of cathepsin D, SDS-PAGE Mus musculus

Expression

Organism Comment Expression
Mus musculus manganese treatment causes significant increase of lysosomal enzyme cathepsin D up