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Literature summary for 3.4.23.5 extracted from
- Pleiotropic effects of cathepsin D (2009), Endocr. Metab. Immune Disord. Drug Targets, 9, 385-391.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A38V | the mutation is linked with Alzheimers disease | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
mature active enzyme form | Homo sapiens |
| 48000 | - |
single chain intermediate active enzyme form | Homo sapiens |
| 52000 | - |
proenzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | Homo sapiens | - |
? | - |
? |  |
| angiostatin + H2O | Homo sapiens | - |
? | - |
? | |
| apolipoprotein E + H2O | Homo sapiens | - |
? | - |
? | |
| endostatin + H2O | Homo sapiens | - |
? | - |
? | |
| prolactin + H2O | Homo sapiens | - |
? | - |
? | |
| tau protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| cerebrospinal fluid | - |
Homo sapiens | - |
| HaCaT cell | - |
Homo sapiens | - |
| keratinocyte | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| macrophage | - |
Homo sapiens | - |
| mammary epithelial cell | - |
Homo sapiens | - |
| ovarian cancer cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
| angiostatin + H2O | - |
Homo sapiens | ? | - |
? | |
| apolipoprotein E + H2O | - |
Homo sapiens | ? | - |
? | |
| endostatin + H2O | - |
Homo sapiens | ? | - |
? | |
| prolactin + H2O | - |
Homo sapiens | ? | - |
? | |
| tau protein + H2O | - |
Homo sapiens | ? | - |
? | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | cathepsin D expression and activity increases during epidermal differentiation | up |
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Release 2023.1 (January 2023)
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