Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.5 extracted from

  • Byun, H.O.; Han, N.K.; Lee, H.J.; Kim, K.B.; Ko, Y.G.; Yoon, G.; Lee, Y.S.; Hong, S.I.; Lee, J.S.
    Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence (2009), Cancer Res., 69, 4638-4647.
    View publication on PubMed
Search for more literature for 3.4.23.5

Application

Application Comment Organism
medicine cathepsin D is a marker for the detection of cellular senescence induced by ionizing radiation of xenografted tumors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A specific inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens cathepsin D is not upregulated during apoptosis induced by 300 nM taxol or 0.01 mg doxorubicin or autophagy induced by 0.01 mM tamoxifen additional information
Homo sapiens senescence induced by ionizing radiation (6 Gy), 0.3 mM hydrogen peroxide or anticancer drugs (40 nM camptothecin, 0.03 mM etoposide, or 50 ng doxorubicin) is associated with up-regulation of cathepsin D up

General Information

General Information Comment Organism
physiological function cathepsin D plays a critical role in cell proliferation Homo sapiens