Literature summary for 3.4.23.5 extracted from

Trincheri, N.F.; Nicotra, G.; Follo, C.; Castino, R.; Isidoro, C.
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D (2007), Carcinogenesis, 28, 922-931.

Search for more literature for 3.4.23.5

Application

Application	Comment	Organism
medicine	results identify the lysosome as a novel target of polyphenol resveratrol activity and demonstrate a hierarchy of the proteolytic pathways involved in its cytotoxic mechanism in which the lysosomal cathepsin D acts upstream of the cytosolic caspase activation. Any metabolic, pharmacologic or genetic conditions affecting cathepsin D expression and/or activity can reflect on the sensitivity of cancer cells to polyphenol resveratrol	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	inhibition of cathepsin D by RNA interference precludes Bax oligomerization, permeabilization of mitochondrial membrane, cytosolic translocation of cytochrome c, caspase 3 activation and polyphenol resveratrol mediated cell death in human colorectal cancer cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
pepstatin A	it is shown that Pepstatin A prevents polyphenol resveratrol (RV)-mediated cytotoxicity in human colorectal cancer cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell line	human colorectal cancer cell line DLD1 and HT29 are used	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
cathepsin D	-	Homo sapiens

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Release 2023.1 (January 2023)