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Literature summary for 3.4.23.5 extracted from

  • Bi, X.; Haque, T.S.; Zhou, J.; Skillman, A.G.; Lin, B.; Lee, C.E.; Kuntz, I.D.; Ellman, J.A.; Lynch, G.
    Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus (2000), J. Neurochem., 74, 1469-1477.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibitors CEL5-A, CEL5-G, EA-1, block production of known precursors to neurofibrillary tangles in hippocampal slices, link of enzyme lysosomal disfunction to the etiology of Alzheimers disease Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
CEL5-A disruption of single- to heavy-chain formation Rattus norvegicus
CEL5-G disruption of single- to heavy-chain formation Rattus norvegicus
EA-1 disruption of single- to heavy-chain formation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus hippocampal slice cultures Rattus norvegicus
-