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Literature summary for 3.4.23.5 extracted from
- Isolation and characterization of cathepsin D from human gasttric mucosa (1981), Collect. Czech. Chem. Commun., 46, 3302-3313.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Diazoacetyl-DL-norleucine methyl ester | - |
Homo sapiens |  |
| Diazoacetylglycine ethyl ester | - |
Homo sapiens | |
| inhibitor isolated from potatoes | - |
Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
Glu-Glu-His-Phe-Phe-Ala-Leu-methyl ester | - |
Homo sapiens | |
| 1.6 | - |
Glu-Glu-His-Phe-Phe-Ala-Ala | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
1 * 18000 + 1 * 33000, SDS-PAGE | Homo sapiens |
| 33000 | - |
1 * 18000 + 1 * 33000, SDS-PAGE | Homo sapiens |
| 49000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | glycoprotein | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric mucosa | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glu-Glu-His-Phe-Phe-Ala-Ala + H2O | - |
Homo sapiens | ? | - |
? | |
| Glu-Glu-His-Phe-Phe-Ala-Leu-methyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 18000 + 1 * 33000, SDS-PAGE | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
Glu-Glu-His-Phe-Phe-Ala-Ala | - |
Homo sapiens | |
| 2.1 | - |
Glu-Glu-His-Phe-Phe-Ala-Leu-methyl ester | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.2 | 3.6 | hemoglobin | Homo sapiens |
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Release 2023.1 (January 2023)
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