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Literature summary for 3.4.23.5 extracted from

  • Watabe, S.; Taguchi, S.; Ikeda, T.; Takada, M.; Yago, N.
    Characterization of cathepsin D in porcine adrenocortical lysosomes (1982), J. Biochem., 92, 45-55.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ 20 mM, 50% inhibition Sus scrofa
pepstatin
-
Sus scrofa
SDS
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Sus scrofa 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13800
-
1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE Sus scrofa
24600
-
1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE Sus scrofa
27400
-
1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE Sus scrofa
42800
-
gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
pig
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Sus scrofa
side-chain modification the three subunits all contain carbohydrate Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O acid-denatured bovine hemoglobin Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
trimer 1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3
-
bovine serum albumin Sus scrofa
3.6
-
acid-denatured bovine hemoglobin Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
20
-
Hg2+
-
Sus scrofa