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Literature summary for 3.4.23.49 extracted from

  • Korhonen, T.K.
    Fibrinolytic and procoagulant activities of Yersinia pestis and Salmonella enterica (2015), J. Thromb. Haemost., 13 Suppl 1, S115-S120 .
    View publication on PubMed
Search for more literature for 3.4.23.49

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha2-antiplasmin + H2O Salmonella enterica subsp. enterica serovar Typhimurium inactivation ?
-
 ?
factor B + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 ?
-
 ?
factor H + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 ?
-
 ?
gelatine + H2O Salmonella enterica subsp. enterica serovar Typhimurium degradation ?
-
 ?
plasminogen + H2O Salmonella enterica subsp. enterica serovar Typhimurium activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin. PgtE addresses the control systems rather than direct plasminogen activation plasmin + ?
-
 ?
plasminogen + H2O Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin. PgtE addresses the control systems rather than direct plasminogen activation plasmin + ?
-
 ?
plasminogen + H2O Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin. PgtE addresses the control systems rather than direct plasminogen activation plasmin + ?
-
 ?
plasminogen activator inhibitor-1 + H2O Salmonella enterica subsp. enterica serovar Typhimurium inactivation ?
-
 ?
TAFI + H2O Salmonella enterica subsp. enterica serovar Typhimurium TAFI is secreted into plasma as a procarboxypeptidase, it is a regulatory protein linking the coagulation and fibrinolytic systems, and TAFI is protective in septic yersionosis. PptE cleaves at the C-terminal region of TAFI and reduces its activation to TAFIa TAFIa + ?
-
 ?
tissue factor pathway inhibitor + H2O Salmonella enterica subsp. enterica serovar Typhimurium TFPI is a major anticoagulant and forms stable TFPI-FXa complexes that block blood clotting. Enzyme PgtE cleaves the tissue factor pathway inhibitor, TFPI ?
-
 ?
tissue factor pathway inhibitor + H2O Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 TFPI is a major anticoagulant and forms stable TFPI-FXa complexes that block blood clotting. Enzyme PgtE cleaves the tissue factor pathway inhibitor, TFPI ?
-
 ?
tissue factor pathway inhibitor + H2O Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 TFPI is a major anticoagulant and forms stable TFPI-FXa complexes that block blood clotting. Enzyme PgtE cleaves the tissue factor pathway inhibitor, TFPI ?
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium P06185
-
-
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 P06185
-
-
Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 P06185
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha2-antiplasmin + H2O inactivation Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
factor B + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
factor H + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
Gelatin + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
Gelatin + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 ?
-
 ?
Gelatin + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ?
-
 ?
gelatine + H2O degradation Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
plasminogen + H2O activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin. PgtE addresses the control systems rather than direct plasminogen activation Salmonella enterica subsp. enterica serovar Typhimurium plasmin + ?
-
 ?
plasminogen + H2O activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin Salmonella enterica subsp. enterica serovar Typhimurium plasmin + ?
-
 ?
plasminogen + H2O activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin. PgtE addresses the control systems rather than direct plasminogen activation Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 plasmin + ?
-
 ?
plasminogen + H2O activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 plasmin + ?
-
 ?
plasminogen + H2O activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin. PgtE addresses the control systems rather than direct plasminogen activation Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 plasmin + ?
-
 ?
plasminogen + H2O activation, but PgtE does not catalyze formation of stable plasmin activity because it cleaves also the B chain of plasmin Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 plasmin + ?
-
 ?
plasminogen activator inhibitor-1 + H2O inactivation Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
TAFI + H2O TAFI is secreted into plasma as a procarboxypeptidase, it is a regulatory protein linking the coagulation and fibrinolytic systems, and TAFI is protective in septic yersionosis. PptE cleaves at the C-terminal region of TAFI and reduces its activation to TAFIa Salmonella enterica subsp. enterica serovar Typhimurium TAFIa + ?
-
 ?
TAFI + H2O cleaves at the C-terminal region of TAFI Salmonella enterica subsp. enterica serovar Typhimurium TAFIa + ?
-
 ?
tissue factor pathway inhibitor + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
tissue factor pathway inhibitor + H2O TFPI is a major anticoagulant and forms stable TFPI-FXa complexes that block blood clotting. Enzyme PgtE cleaves the tissue factor pathway inhibitor, TFPI Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
tissue factor pathway inhibitor + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 ?
-
 ?
tissue factor pathway inhibitor + H2O TFPI is a major anticoagulant and forms stable TFPI-FXa complexes that block blood clotting. Enzyme PgtE cleaves the tissue factor pathway inhibitor, TFPI Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 ?
-
 ?
tissue factor pathway inhibitor + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ?
-
 ?
tissue factor pathway inhibitor + H2O TFPI is a major anticoagulant and forms stable TFPI-FXa complexes that block blood clotting. Enzyme PgtE cleaves the tissue factor pathway inhibitor, TFPI Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ?
-
 ?

Synonyms

Synonyms Comment Organism
PgtE
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Expression

Organism Comment Expression
Salmonella enterica subsp. enterica serovar Typhimurium PgtE of Salmonella enterica is not expressed under normal laboratory conditions, but the transcription of pgtE is high in mouse macrophages where the degradation of alpha2AP by Salmonella enterica cells also is high. Expression of PgtE is regulated by the SlyA regulator additional information

General Information

General Information Comment Organism
metabolism expression of PgtE is regulated by the SlyA regulator, which, on the other hand, is regulated by the PhoP/Q regulatory system which senses and responses to alpha-helical cationic antimicrobial peptides that are substrates for PgtE degradation Salmonella enterica subsp. enterica serovar Typhimurium
physiological function PgtE of the enteropathogen Salmonella enterica is a surface-exposed, transmembrane beta-barrel proteases of the omptin family that exhibit a complex array of interactions with the hemostatic systems in vitro, the protease is an established virulence factor. PgtE proteolysis targets control aspects of fibrinolysis, and mimicry of matrix metalloproteinases enhances cell migration that should favor the intracellular spread of the bacterium. The enzymatic activity of the protease is strongly influenced by the environment-induced variations in lipopolysaccharide that binds to the beta-barrel. The protease cleaves the tissue factor pathway inhibitor and thus also expresses procoagulant activity. PgtE effectively suppresses the regulatory proteins PAI-1, alpha2AP, and TAFI and activates scu-PA to active urokinase. PgtE addresses the control systems rather than direct plasminogen activation. Another mechanism by which PgtE can enhance cell motility and bacteria-phagocyte encounters is its ability to degrade gelatine and to activate the matrix metalloproteinase 9 (procollagenase) secreted from macrophages. PgtE also enhances multiplication of Salmonella enterica inside murine macrophages, where degradation of cationic antimicrobial peptides seems an important function of PgtE. PgtE also inactivates the complement regulatory proteins factors B and H and reduces opsonophacytosis of Salmonella enterica Salmonella enterica subsp. enterica serovar Typhimurium