Cloned (Comment) | Organism |
---|---|
tetracycline-responsive promoter system in Yersinia pestis applied to control primary pneumonic plague progression after activation/inhibition of plasminogen activator Pla expression | Yersinia pestis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Yersinia pestis | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yersinia pestis | P17811 | wild-type strain CO92, isogenic strain lacking Pla (CO92 DELTA-pla) and complemented CO92 DELTA-pla strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | C57BL/6 mice infected with Yersinia pestis | Yersinia pestis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
kinetics of infection summarized, lack of plasminogen activator Pla shown to delay the time to death resulting from respiratory infection of mice, plasminogen activator Pla shown to control proliferation of Yersinia pestis in the lungs but is not essential for bacteria to disseminate, aborted inflammation and activated lung repair shown in absence of expression of plasminogen activator Pla | Yersinia pestis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Yersinia pestis | plasmin + ? | - |
? | |
plasminogen + H2O | plasminogen activator Pla shown to be essential to cause primary pneumonic plague, minor importance determined for dissemination during pneumonic plague than during bubonic plague, inhibition of plasminogen activator Pla expression shown to prolong survival of infected mice | Yersinia pestis | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
plasminogen activator Pla | - |
Yersinia pestis |