Literature summary for 3.4.23.48 extracted from

Benedek, O.; Khan, A.S.; Schneider, G.; Nagy, G.; Autar, R.; Pieters, R.J.; Emody, L.
Identification of laminin-binding motifs of Yersinia pestis plasminogen activator by phage display (2005), Int. J. Med. Microbiol., 295, 87-98.

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Protein Variants

Protein Variants	Comment	Organism
G178A/L179A	mutation decreases laminin binding in the YPYIPTL region	Yersinia pestis
L65A/T66A/L67A	mutation decreases laminin binding in the WSLLTPA region	Yersinia pestis

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	WSLLTPAand YPYIPLT inhibit laminin binding activity of plasmonogen activator	Yersinia pestis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
plasminogen + H2O	Yersinia pestis	plasminogen activator is a surface virulence factor that contributes to the highly imvasive nature of the pathogen by binding various tissue matrix components	plasmin + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Yersinia pestis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
plasminogen + H2O	plasminogen activator is a surface virulence factor that contributes to the highly imvasive nature of the pathogen by binding various tissue matrix components	Yersinia pestis	plasmin + ?	-	?

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Release 2023.1 (January 2023)