Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PAI-1 | inhibition of tissue-type plasminogen activator and urokinase | Mammalia | |
PAI-2 | inhibition of urokinase | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Mammalia | activates plasminogen by cleaving the Arg560-Val561 bond | plasmin + ? | - |
? | |
plasminogen + H2O | Yersinia pestis | activates plasminogen by cleaving the Arg560-Val561 bond | plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
tissue-type plasminogen activator and urokinase | - |
Mycobacterium tuberculosis | - |
- |
- |
Streptococcus uberis | - |
mechanism of plasminogen activation is not known | - |
Yersinia pestis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | activates plasminogen by cleaving the Arg560-Val561 bond | Mammalia | plasmin + ? | - |
? | |
plasminogen + H2O | activates plasminogen by cleaving the Arg560-Val561 bond | Yersinia pestis | plasmin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | Pla occurs in 3 processed forms of alpha-Pla, beta-Pla and gamma-Pla, of which alpha-Pla with an apparant molecular mass of 37000 Da, corresponds to full-size mature Pla, and beta-Pla and gamma-Pla with molecular weights of 31000 Da and 35000 Da respectively, are thought to result from processing of alpha-Pla, beta-Pla may result from an autoprocessing event | Yersinia pestis |