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Literature summary for 3.4.23.48 extracted from

  • Lahteenmaki, K.; Kukkonen, M.; Korhonen, T.K.
    The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells (2001), FEBS Lett., 504, 69-72.
    View publication on PubMed
Search for more literature for 3.4.23.48

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Yersinia pestis

Protein Variants

Protein Variants Comment Organism
D206A proteolytic activity is abolished Yersinia pestis
S99A proteolytic activity is abolished Yersinia pestis

Localization

Localization Comment Organism GeneOntology No. Textmining
outer membrane
-
 Yersinia pestis 19867
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Yersinia pestis Pla belongs to the omptin family of enterobacterial surface proteases and is responsible for the highly efficient invasion of the plague bacterium from the subcutaneous infection site into the circulation plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Yersinia pestis
-
 Pla mediates bacterial invasion into human endothelial cells independently of its proteolytic activity
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O Pla belongs to the omptin family of enterobacterial surface proteases and is responsible for the highly efficient invasion of the plague bacterium from the subcutaneous infection site into the circulation Yersinia pestis plasmin + ?
-
 ?