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Literature summary for 3.4.23.47 extracted from

  • Masse, S.; Lu, X.; Dekhtyar, T.; Lu, L.; Koev, G.; Gao, F.; Mo, H.; Kempf, D.; Bernstein, B.; Hanna, G.J.; Molla, A.
    In vitro selection and characterization of human immunodeficiency virus type 2 with decreased susceptibility to lopinavir (2007), Antimicrob. Agents Chemother., 51, 3075-3080.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
V47A/D17N passage of HIV-2MS with increasing concentrations of lopinavir selects mutations V47A and D17N in the HIV-2 protease gene. Introduction of both 17N and 47A either individually or together into HIV-2ROD molecular infectious clones shows that the single V47A substitution in HIV-2 results in a substantial reduction in susceptibility to lopinavir. This mutant retains wild-type susceptibility to other proteinase inhibitors and is hypersusceptible to atazanavir and saquinavir Human immunodeficiency virus 2

Inhibitors

Inhibitors Comment Organism Structure
atazanavir
-
 Human immunodeficiency virus 2
lopinavir activity of lopinavir against three strains of HIV-2 is assessed and compared to activity against a reference HIV-1 strain. Lopinavir demonstrates activity similar to that observed against HIV-1 in two HIV-2 strains (HIV-2MS and HIV-2CBL-23) tested. 10fold reduced susceptibility is observed using strain HIV-2CDC310319 Human immunodeficiency virus 2
squinavir
-
 Human immunodeficiency virus 2

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 2
-
-
-

Synonyms

Synonyms Comment Organism
PR
-
 Human immunodeficiency virus 2