Crystallization (Comment) | Organism |
---|---|
crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 | Human immunodeficiency virus 2 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.099 | - |
VLQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.172 | - |
VSQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.203 | - |
VSQLYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.223 | - |
VSQNYPLVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GAG precursor protein of HIV-2 + H2O | Human immunodeficiency virus 2 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 2 | - |
human immunodeficiency virus type 2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GAG precursor protein of HIV-2 + H2O | - |
Human immunodeficiency virus 2 | ? | - |
? | |
VLQNYPIVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VLQNY + PIVQ | - |
? | |
VSQLYPIVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VSQLY + PIVQ | - |
? | |
VSQNYPIVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VSQNY + PIVQ | - |
? | |
VSQNYPLVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VSQNY + PLVQ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Human immunodeficiency virus 2 |
Synonyms | Comment | Organism |
---|---|---|
retroviral aspartic proteinase | - |
Human immunodeficiency virus 2 |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000333 | - |
VLQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.0011 | - |
VSQLYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00213 | - |
VSQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00303 | - |
VSQNYPLVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 |