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Literature summary for 3.4.23.47 extracted from

  • Tong, L.; Pav, S.; Pargellis, C.; Do, F.; Lamarre, D.; Anderson, P.C.
    Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures (1993), Proc. Natl. Acad. Sci. USA, 90, 8387-8391.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2 Human immunodeficiency virus 2

Cloned(Commentary)

Cloned (Comment) Organism
cloned and expressed in Escherichia coli BL21 Human immunodeficiency virus 2

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 Human immunodeficiency virus 2
Phe-Val-Phe-psi-CH2NH-Leu-Glu-Ile-amide, space group P4(1) or P4(3), unit-cell parameters a=b=55.1 A, c=138.9 A Human immunodeficiency virus 2

Inhibitors

Inhibitors Comment Organism Structure
Phe-Val-Phe-psi-[CH2NH]-Leu-Glu-Ile-amide
-
 Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GAG precursor protein of HIV-2 + H2O Human immunodeficiency virus 2 protease is responsible for processing of the gag structural polyprotein and the release of virally encoded enzymes like protease, reverse transcriptase and integrase from the gag-pol fusion protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 2
-
 human immunodeficiency virus type 2
-

Purification (Commentary)

Purification (Comment) Organism
-
 Human immunodeficiency virus 2

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GAG precursor protein of HIV-2 + H2O protease is responsible for processing of the gag structural polyprotein and the release of virally encoded enzymes like protease, reverse transcriptase and integrase from the gag-pol fusion protein Human immunodeficiency virus 2 ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Human immunodeficiency virus 2