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Literature summary for 3.4.23.46 extracted from

  • Yu, T.; Paudel, P.; Seong, S.H.; Kim, J.A.; Jung, H.A.; Choi, J.S.
    Computational insights into beta-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations (2018), Comput. Biol. Chem., 74, 273-285 .
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
15,16-dihydrotanshinone
-
 Homo sapiens
2-amino-3-[(1R)-1-cyclohexyl-2-[(cyclohexylcarbonyl)amino]ethyl]-6-phenoxyquinazolin-3-ium
-
 Homo sapiens
4',5,7-trimethoxyflavone
-
 Homo sapiens
caffeic acid
-
 Homo sapiens
cryptotanshinone
-
 Homo sapiens
dehydrodanshenol A
-
 Homo sapiens
deoxyneocryptotanshinone mixed-type inhibition Homo sapiens
ferruginol
-
 Homo sapiens
grandifolia F
-
 Homo sapiens
magnesium lithospermate
-
 Homo sapiens
methyl tanshinonate
-
 Homo sapiens
quercetin
-
 Homo sapiens
rosmarinic acid
-
 Homo sapiens
salvianolic acid A competitive type inhibition Homo sapiens
salvianolic acid B
-
 Homo sapiens
salvianolic acid C mixed-type inhibition Homo sapiens
tanshinol B
-
 Homo sapiens
tanshinonal
-
 Homo sapiens
tanshinone I
-
 Homo sapiens
tanshinone IIA
-
 Homo sapiens
tanshinone IIB
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
Rh-EVNLDAEFK-quencher + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
beta-site amyloid precursor protein enzyme 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00918
-
 at pH 4.5 and 23°C Homo sapiens salvianolic acid C
0.01049
-
 at pH 4.5 and 23°C Homo sapiens quercetin
0.01153
-
 at pH 4.5 and 23°C Homo sapiens deoxyneocryptotanshinone
0.01301
-
 at pH 4.5 and 23°C Homo sapiens salvianolic acid A
0.02846
-
 at pH 4.5 and 23°C Homo sapiens tanshinone I
0.02977
-
 at pH 4.5 and 23°C Homo sapiens rosmarinic acid
0.03034
-
 at pH 4.5 and 23°C Homo sapiens dehydrodanshenol A
0.03035
-
 at pH 4.5 and 23°C Homo sapiens magnesium lithospermate
0.03402
-
 at pH 4.5 and 23°C Homo sapiens tanshinonal
0.0356
-
 at pH 4.5 and 23°C Homo sapiens methyl tanshinonate
0.03995
-
 at pH 4.5 and 23°C Homo sapiens cryptotanshinone
0.04863
-
 at pH 4.5 and 23°C Homo sapiens 15,16-dihydrotanshinone
0.09186
-
 at pH 4.5 and 23°C Homo sapiens tanshinone IIA
0.09822
-
 at pH 4.5 and 23°C Homo sapiens tanshinol B
0.10306
-
 at pH 4.5 and 23°C Homo sapiens grandifolia F
0.2
-
 at pH 4.5 and 23°C Homo sapiens caffeic acid
0.2
-
 at pH 4.5 and 23°C Homo sapiens ferruginol
0.2
-
 at pH 4.5 and 23°C Homo sapiens tanshinone IIB