Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-fluoro-1-(pyridin-4-yl)-1-[3-(pyrimidin-5-yl)phenyl]-1H-isoindol-3-amine | i.e. AZ2000. Inhibitor with improved brain disposition, reduces amyloid beta levels in both brain and periphery already after acute dosing. Mice heterozygous for BACE1, display a 62% reduction in plasma amyloid beta40 levels, whereas brain amyloid beta40 is only lowered by 11% | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P56818 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | selective inhibition of peripheral BACE1 activity in wild-type mice or mice over-expressing amyloid precursor protein reduces amyloid beta levels in the periphery but not in the brain, not even after chronic treatment over several months. BACE1 inhibitor 4-fluoro-1-(pyridin-4-yl)-1-[3-(pyrimidin-5-yl)phenyl]-1H-isoindol-3-amine with improved brain disposition reduces amyloid beta levels in both brain and periphery already after acute dosing. Mice heterozygous for BACE1, display a 62% reduction in plasma amyloid beta40 levels, whereas brain amyloid beta40 is only lowered by 11% | Mus musculus |