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Literature summary for 3.4.23.46 extracted from
- Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2? pathway (2012), Biochim. Biophys. Acta, 1822, 885-896.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | activated double-stranded RNA dependant protein kinase PKR and activated eukaryotic translation initiation factor eIF2alpha and BACE1 levels are increased in Alzheimer's disease cortices and BACE1 correlates with phosphorylated eIF2alpha levels. BACE1 protein levels are increased in response to oxidative stress in SH-SY5Y cells and specific inhibitions of PKR-eIF2alpha attenuate BACE1 protein levels in this model | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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