Literature summary for 3.4.23.46 extracted from

Sasaki, H.; Miki, K.; Kinoshita, K.; Koyama, K.; Juliawaty, L.D.; Achmad, S.A.; Hakim, E.H.; Kaneda, M.; Takahashi, K.
beta-Secretase (BACE-1) inhibitory effect of biflavonoids (2010), Bioorg. Med. Chem. Lett., 20, 4558-4560.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-dihydro-6-methylginkgetin	isolated from from Cephalotaxus harringtonia var. fastigiata	Homo sapiens
2,3-dihydroamentoflavone	a 2,3-dihydroamentoflavone from Cycas revoluta	Homo sapiens
additional information	presence of a flavanone moiety in the amentoflavone biflavonoid is advantageous for inhibitory activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P56817	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00035	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	2,3-dihydro-6-methylginkgetin
0.00075	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	2,3-dihydroamentoflavone

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Release 2023.1 (January 2023)