Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-oxo-N-(pyridin-4-yl)-10,11-dihydro-5H-dibenzo[b,e][1,4]-diazepine-3-carboxamide | - |
Homo sapiens | |
3-(3H-imidazo[4,5-c]pyridin-2-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one | - |
Homo sapiens | |
3-(5-(4-fluorophenyl)-1H-imidazol-2-yl)-5H dibenzo[b,e][1,4]diazepin-11(10H)-one | - |
Homo sapiens | |
3-(5-(pyridin-4-yl)-1H-imidazol-2-yl)-5H dibenzo[b,e][1,4]-diazepin-11(10H)-one | - |
Homo sapiens | |
3-(6-fluoro-1H-benzo[d]imidazol-2-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one | - |
Homo sapiens | |
N-(4-fluorophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e]-[1,4]diazepine-3-carboxamide | - |
Homo sapiens | |
N-[(2S,3S)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-N'-[(1R)-1-(4-fluorophenyl)ethyl]-5-[(methylsulfonyl)amino]benzene-1,3-dicarboxamide | - |
Homo sapiens | |
OM99-2 | i.e. Glu-Val-Asn-(S)-CH(OH)CH2-Leu-Ala-Glu-Phe-OH | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? | |
rhodamine-EVNLDAEFK-DABCYL + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000016 | - |
OM99-2 | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.00001 | - |
N-[(2S,3S)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-N'-[(1R)-1-(4-fluorophenyl)ethyl]-5-[(methylsulfonyl)amino]benzene-1,3-dicarboxamide | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.000211 | - |
N-(4-fluorophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e]-[1,4]diazepine-3-carboxamide | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.000244 | - |
3-(6-fluoro-1H-benzo[d]imidazol-2-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.000293 | - |
3-(5-(4-fluorophenyl)-1H-imidazol-2-yl)-5H dibenzo[b,e][1,4]diazepin-11(10H)-one | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.000295 | - |
11-oxo-N-(pyridin-4-yl)-10,11-dihydro-5H-dibenzo[b,e][1,4]-diazepine-3-carboxamide | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.000309 | - |
3-(3H-imidazo[4,5-c]pyridin-2-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens | |
0.000348 | - |
3-(5-(pyridin-4-yl)-1H-imidazol-2-yl)-5H dibenzo[b,e][1,4]-diazepin-11(10H)-one | in 50 mM sodium acetate buffer, pH 4.5, at 25°C | Homo sapiens |