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Literature summary for 3.4.23.46 extracted from

  • Yamakawa, H.; Yagishita, S.; Futai, E.; Ishiura, S.
    beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein (2010), J. Biol. Chem., 285, 1634-1642.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
beta-secretase inhibitor IV complete inhibition at 0.001 mM Homo sapiens
OM99-2 complete inhibition at 0.0001 nM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Homo sapiens fragments of amyloid precursor protein
-
 ?
SEVKMDAEFRHDSGYEK-biotin + H2O
-
 Homo sapiens ?
-
 ?
SEVNLDAEFRHDSGYEK-biotin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
BACE1/beta-secretase
-
 Homo sapiens
beta-secretase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000024
-
 using SEVNLDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication Homo sapiens OM99-2
0.0000033
-
 using SEVKMDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication Homo sapiens OM99-2
0.0000098
-
 using SEVNLDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication Homo sapiens beta-secretase inhibitor IV
0.0000124
-
 using SEVKMDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication Homo sapiens beta-secretase inhibitor IV