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Literature summary for 3.4.23.46 extracted from
- Statins and the squalene Ssnthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis (2010), J. Alzheimers Dis., 20, 1215-1231.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| SH-SY5Y cell | addition of a GPI-anchor to BACE targets the enzyme exclusively to lipid raft domains | Homo sapiens | - |
| SK-N-MC cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the mRNA level of BACE1 is not regulated by lovestatin | additional information |
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Release 2023.1 (January 2023)
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