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Literature summary for 3.4.23.46 extracted from

  • Sala Frigerio, C.; Fadeeva, J.V.; Minogue, A.M.; Citron, M.; Van Leuven, F.; Staufenbiel, M.; Paganetti, P.; Selkoe, D.J.; Walsh, D.M.
    beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins (2010), FEBS J., 277, 1503-1518.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein + H2O Homo sapiens
-
fragments of beta-amyloid precursor protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
Homo sapiens fragments of beta-amyloid precursor protein
-
?

Synonyms

Synonyms Comment Organism
BACE-1
-
Homo sapiens
beta-secretase
-
Homo sapiens
beta-site APP-cleaving enzyme 1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function BACE1 is involved in regulating ectodomain shedding, maturation and trafficking of the amyloid precursor protein family of proteins. BACE1 expression regulates the levels and species of full-length amyloid precursor-like protein 1, amyloid precursor protein, and amyloid precursor-like protein 2, of their shed ectodomains, and of their membrane-bound C-terminal fragments Homo sapiens