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Literature summary for 3.4.23.46 extracted from

  • Arslanova, D.; Yang, T.; Xu, X.; Wong, S.T.; Augelli-Szafran, C.E.; Xia, W.
    Phenotypic analysis of images of zebrafish treated with Alzheimers gamma-secretase inhibitors (2010), BMC Biotechnol., 10, 24.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
AD115 a fragment of Gleevec Danio rerio
AD28 a fragment of Gleevec Danio rerio
AD94 a fragment of Gleevec Danio rerio
AD95 a fragment of Gleevec, strong inhibition Danio rerio
Gleevec
-
Danio rerio
N- [N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine tert-butyl ester complete inhibition at 0.1 mM Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Danio rerio
-
amyloid beta protein 40 + amyloid beta protein 42
-
?
Notch + H2O Danio rerio
-
Notch intracellular domain + ?
-
?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
Danio rerio amyloid beta protein 40 + amyloid beta protein 42
-
?
Notch + H2O
-
Danio rerio Notch intracellular domain + ?
-
?

Synonyms

Synonyms Comment Organism
gamma-secretase
-
Danio rerio