Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.46 extracted from

  • Xiong, M.; Zhang, T.; Zhang, L.M.; Lu, S.D.; Huang, Y.L.; Sun, F.Y.
    Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke (2008), Neurobiol. Dis., 32, 433-441.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information caspase-3 inhibitor Z-DEVD-FMK reduces BACE1 mRNA and protein levels, and inhibits its protease activity, thereby decreasing the amount of amyloid precursor protein C99 and amyloid beta in ischemic brains. Caspase-3 inhibition attenuates ischemia-induced amyloid beta-formation by reducing BACE1 production and activity Rattus norvegicus
Z-DEVD-FMK caspase-3 inhibitor Z-DEVD-FMK reduces BACE1 mRNA and protein levels, and inhibits its protease activity, thereby decreasing the amount of amyloid precursor protein C99 and beta-amyloid in ischemic brains Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
corpus striatum BACE1 is significantly and time-dependently increased in the ipsilateral striatum Rattus norvegicus
-
corpus striatum changes in caspase-3, amyloid beta and BACE1 levels are detected in rat striatum on different days after middle cerebral artery occlusion using immunostaining. The positive labeled cells of activated caspase-3, amyloid beta, and BACE1 are significantly and time-dependently increased in the ipsilateral striatum Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein APP + H2O
-
Rattus norvegicus beta-amyloid protein + beta-amyloid precursor protein pre-peptide
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Rattus norvegicus
beta-secretase
-
Rattus norvegicus