Activating Compound | Comment | Organism | Structure |
---|---|---|---|
4-hydroxynonenal | induction of BACE1 expression under oxidative stress determined | Mus musculus | |
H2O2 | induction of BACE1 expression under oxidative stress determined | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P56818 | BalbC mice | - |
Mus musculus BalbC | P56818 | BalbC mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cytosolic and nuclear extracts of mouse brain tissues | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
oxidative stress measured in cytosolic fractions, antibodies and immunoblot analysis performed, RNA interference and Luciferase reporter gene assay applied, stimulation of BACE1 expression by oxidative stress determined, mechanism shown to require gamma-secretase activity involving the c-jun N-terminal kinase (JNK)/c-jun pathway, inceased BACE1 levels identified in normal cells, but not in cells lacking presenilins or amyloid precursor protein, correlation with activation of JNK and c-jun determined | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | BACE1 expression shown to be stimulated by oxidative stress, mechanism of transcriptional induction of BACE1 by oxidative stress discussed as a contribution to production of pathological levels of amyloid beta protein in Alzheimer disease | Mus musculus | ? | - |
? | |
additional information | BACE1 expression shown to be stimulated by oxidative stress, mechanism of transcriptional induction of BACE1 by oxidative stress discussed as a contribution to production of pathological levels of amyloid beta protein in Alzheimer disease | Mus musculus BalbC | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Mus musculus |
beta-secretase | - |
Mus musculus |