Literature summary for 3.4.23.46 extracted from

Lahiri, D.K.; Maloney, B.; Ge, Y.W.
BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation (2006), J. Mol. Neurosci., 28, 193-210.

Search for more literature for 3.4.23.46

Protein Variants

Protein Variants	Comment	Organism
additional information	BACE1-driven reporter protein expression, transfection of rat cortical cultures	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P56817	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioblastoma cell line	glioblastoma-astrocytoma cell line U373, nuclear extracts used for promoter-protein binding studies	Homo sapiens	-
HeLa cell	nuclear extracts used for promoter-protein binding studies, hypoxic cells included	Homo sapiens	-
lymphoma cell line	U937, nuclear extracts used for promoter-protein binding studies	Homo sapiens	-
neuroblastoma cell line	NB, nuclear extracts used for promoter-protein binding studies	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	characterization of structure and regulatory region of the beta-secretase BACE1 promoter, more repetitive elements in BACE1 than in BACE2 identified, regulatory domains of BACE1 promoter shown to be different from those of BACE2, DNA-protein interaction studies performed, BACE1-driven reporter protein expression shown to be higher than those of BACE2, operation of BACE1 through a single transcriptional control site suggested, differences to BACE2 summarized, genomic mapping of BACE1 and BACE2 on chromosome and of functional domains performed	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	structure and regulatory elements of beta-secretase BACE1 promoter analyzed, comparative model of transcriptional regulation between BACE1 and BACE2 presented	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Homo sapiens
beta-secretase	-	Homo sapiens

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Release 2023.1 (January 2023)