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Literature summary for 3.4.23.46 extracted from
- Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s) (2008), Biol. Chem., 389, 313-320.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | ratio kcat/Km for substrates SEVKMDAEFR and EEISEVKMDAEFRG is 53.3 per M and s and 95 per M and s, respectively | Homo sapiens | |
| 1.71 | - |
EEISEVNLDAEFRG | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens |  |
| 1.71 | - |
EEISEVNLDAEFRG | pH 3.8, 37°C | Homo sapiens | |
| 4.07 | - |
SEVNLDAEFR | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
| 4.07 | - |
SEVNLDAEFR | pH 3.8, 37°C | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | both BACE1 and human cathepsin D show poor activity towards the wild-type amyloid beta-site sequence | Homo sapiens | - |
| cerebral cortex | - |
Homo sapiens | - |
| hippocampus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein APP + H2O | - |
Homo sapiens | beta-amyloid protein + beta-amyloid precursor protein pre-peptide | - |
? | |
| EEISEVKMDAEFRG + H2O | - |
Homo sapiens | EEISEVKM + DAEFRG | - |
? | |
| EEISEVNLDAEFRG + H2O | - |
Homo sapiens | EEISEVNL + DAEFRG | - |
? | |
| SEVKMDAEFR + H2O | - |
Homo sapiens | SEVKM + DAEFR | - |
? | |
| SEVNLDAEFR + H2O | - |
Homo sapiens | SEVNL + DAEFR | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10.7 | - |
SEVNLDAEFR | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
| 10.7 | - |
SEVNLDAEFR | pH 3.8, 37°C | Homo sapiens | |
| 17.6 | - |
EEISEVNLDAEFRG | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
| 17.6 | - |
EEISEVNLDAEFRG | pH 3.8, 37°C | Homo sapiens | |
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