Literature summary for 3.4.23.45 extracted from

Rochin, L.; Hurbain, I.; Serneels, L.; Fort, C.; Watt, B.; Leblanc, P.; Marks, M.S.; De Strooper, B.; Raposo, G.; van Niel, G.
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells (2013), Proc. Natl. Acad. Sci. USA, 110, 10658-10663.

Search for more literature for 3.4.23.45

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pigment cell-specific melanocyte protein + H2O	Mus musculus	-	?	BACE2 processes pigment cell-specific melanocyte protein to generate functional amyloids. BACE2 cleaves the integral membrane form of pigment cell-specific melanocyte protein within the juxtamembrane domain, releasing the luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JL18	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pigment cell-specific melanocyte protein + H2O	-	Mus musculus	?	BACE2 processes pigment cell-specific melanocyte protein to generate functional amyloids. BACE2 cleaves the integral membrane form of pigment cell-specific melanocyte protein within the juxtamembrane domain, releasing the luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis	?

General Information

General Information	Comment	Organism
physiological function	BACE2 is highly expressed in pigment cells and homozygous Bace2 mutant mice display coat color defects, implying a specific role for BACE2 during melanogenesis	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)