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BRENDA support

Literature summary for 3.4.23.45 extracted from

  • van Bebber, F.; Hruscha, A.; Willem, M.; Schmid, B.; Haass, C.
    Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes (2013), J. Neurochem., 127, 471-481.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Danio rerio X4Z0F5
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function mutations in Bace2 reveal a distinct melanocyte migration phenotype, which is not observed in homozygous Bace1 mutants. Double homozygous Bace1/Bace2 fish do not enhance the single mutant phenotypes indicating non-redundant distinct physiological functions. Single homozygous bace1 mutants as well as double homozygous bace1 and bace2 mutants are viable and fertile Danio rerio