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Literature summary for 3.4.23.45 extracted from
- beta-Secretase: structure, function, and evolution (2008), CNS Neurol. Disord. Drug Targets, 7, 278-294.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | BACE-2 exhibits secretase activity with cleavage in the middle of the amyloid peptide domain at amino acids 19 and 20 generating a carboxy-terminal fragment of 79 residues, and does not contribute to the process of amyloid peptide generation, BACE-2 can cleave at the beta-site, but consistent with its different substrate specificity, does not cleave a preferred peptide-based BACE-1 substrate | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE-1 homologue | - |
Homo sapiens |
| BACE-2 | - |
Homo sapiens |
| beta site APP cleaving enzyme | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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