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Literature summary for 3.4.23.45 extracted from

  • Kuhn, P.H.; Marjaux, E.; Imhof, A.; De Strooper, B.; Haass, C.; Lichtenthaler, S.F.
    Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase (2007), J. Biol. Chem., 282, 11982-11995.
    View publication on PubMed
Search for more literature for 3.4.23.45

Cloned(Commentary)

Cloned (Comment) Organism
expressed together with full length IL-IR2 or truncated form DELTA322-IL-1R2 in HEK 293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
 fragments of amyloid precursor protein
-
 ?
IL-1R2 + H2O Homo sapiens cleavage produces fragments which are almost identical to those produced by alpha-sectretase, enzyme might act in an alternative alpha-sectretase like cleavage fragments of IL-1R2 cleavage between Phe329 and Gln330 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Homo sapiens fragments of amyloid precursor protein
-
 ?
DELTA322-IL-1R2 + H2O truncated protein cotransfected with the enzyme in HEK 293 Homo sapiens fragments of DELTA322-IL-1R2 cleavage in the same manner as for the full length protein with cleavage between Phe329 and Gln330 ?
IL-1R2 + H2O cleavage produces fragments which are almost identical to those produced by alpha-sectretase, enzyme might act in an alternative alpha-sectretase like cleavage Homo sapiens fragments of IL-1R2 cleavage between Phe329 and Gln330 ?
IL-1R2 + H2O intact recombinant protein with a mass of 2219.7 Da Homo sapiens fragments of IL-1R2 fragments with masses of 916.7 Da and 1321 Da indicating a cleavage between Phe329 and Gln330 ?
IL-1R2 + H2O synthetic peptide from Val322 to Ser341 Homo sapiens ?
-
 ?
additional information P-selctin, TNF-alpha and CD14 are not cleaved Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE2 homologue to BACE1 Homo sapiens