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Literature summary for 3.4.23.45 extracted from

  • Stockley, J.H.; O'Neill, C.
    The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimers disease brain (2007), Biochem. Soc. Trans., 35, 574-576.
    View publication on PubMed
Search for more literature for 3.4.23.45

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens cleavage at the beta site of amyloid precursor protein but preferably between Phe690 and Phe691 or Phe691 and Ala692 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 enzyme level is decreased in Alzheimer’s disease patients
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Reaction

Reaction Comment Organism Reaction ID
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein preferential cleavage of the amyloid precursor protein between Phe690 and Phe691 or Phe691 and Ala692 Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain low mRNA level in the brain compared with other organs, 10fold lower mRNA level in the brain compared with BACE1 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O cleavage at the beta site of amyloid precursor protein but preferably between Phe690 and Phe691 or Phe691 and Ala692 Homo sapiens fragments of amyloid precursor protein
-
 ?

Subunits

Subunits Comment Organism
? 73000-75000 Da Homo sapiens

Synonyms

Synonyms Comment Organism
BACE2 homologue to BACE1, which cleaves amyloid precursor protein at the beta site but preferably after Phe690 or Phe691 Homo sapiens
beta-site APP cleaving enzyme
-
 Homo sapiens
More subgroup of the A1 aspartyl protease family Homo sapiens